5-HTP
What Is 5-HTP?
5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid and chemical precursor to serotonin. It is commonly used to support mood, sleep quality, and appetite regulation by increasing serotonin levels in the brain.
5-HTP Research & Studies
01 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology ▸
Comprehensive review covering 5-HTP's role in neurological and metabolic health, discussing its production and uses in treating depression and anxiety.
View Study (PubMed)02 Tryptophan-enriched diet or 5-hydroxytryptophan supplementation given in a randomized controlled trial impacts social cognition ▸
Study found 5-HTP influences social cognition, particularly in interpreting moral and emotional cues, with increased empathy-related brain activity.
View Study (PubMed)03 The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults ▸
Twelve-week trial demonstrated 5-HTP improved sleep quality and increased microbiota diversity in older adults.
View Study (PubMed)04 Advances in the Microbial Synthesis of 5-Hydroxytryptophan ▸
Review discussing recent advancements in microbial methods for 5-HTP production, improving biosynthesis efficiency.
View Study (PubMed)05 Simultaneous determination of 5-hydroxytryptophan and 3-O-methyldopa in dried blood spot by UPLC-MS/MS ▸
Study developed a diagnostic method to measure 5-HTP, aiding detection of L-amino acid decarboxylase deficiency.
View Study (ScienceDirect)06 Amines and the rat exocrine pancreas: Effects of receptor blockers on turnover of L-5HTP ▸
Research studied 5-HTP metabolism in the pancreas, showing changes in serotonin accumulation with receptor blockers.
View Study (ScienceDirect)07 Analgesic effects of N-acetyl-5HTP-5HTP amide are not directly related to brain serotonin levels ▸
Synthetic 5-HTP dipeptide increased pain thresholds in rats through an alternate pathway independent of serotonin.
View Study (ScienceDirect)08 HVA and 5HIAA CSF measurements and 5HTP trials in some patients with involuntary movements ▸
5-HTP trials showed selective therapeutic benefit in specific myoclonus conditions while worsening symptoms in other movement types.
View Study (ScienceDirect)09 Effect of L-5HTP on Tremorine- or Oxotremorine-Induced Tremor in Mice and Rats ▸
Study examined 5-HTP's potential for managing tremors and muscle rigidity, relevant to Parkinson's research.
View Study (ScienceDirect)5-HTP User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Users generally report positive effects on mood and sleep, though some experience digestive side effects initially.
5-HTP Benefits, Dosage & Side Effects
- Mood Enhancement: Many users report improved mood and reduced anxiety within days to weeks of supplementation.
- Sleep Quality: Commonly used as a sleep aid, users report falling asleep faster and experiencing deeper sleep.
- Appetite Suppression: Some users notice reduced cravings and appetite, supporting weight management efforts.
- Variable Response: Effectiveness varies significantly among individuals, with some experiencing dramatic improvements and others noticing minimal change.
- Works Best With Cofactors: Users report better results when combining with B6 and other cofactors that support serotonin synthesis.
- Typical Range: 50-300mg daily, often taken in divided doses.
- Timing: Usually taken with meals or before bed depending on the desired effect.
- Start Low: New users often start at 50mg and gradually increase to assess tolerance.
- Digestive Issues: Nausea and digestive discomfort are common initially but often subside.
- Serotonin Syndrome Risk: Should not be combined with SSRIs or other serotonergic medications.
- Drowsiness: May cause drowsiness, particularly at higher doses.
- Widely Available: Found in most supplement stores and online retailers.
- Affordable: Generally inexpensive compared to many nootropics.
Community Reviews
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