Agmatine
What Is Agmatine?
Agmatine is a metabolite of L-arginine with diverse neuromodulatory effects. It acts on multiple receptor systems including NMDA, imidazoline, and alpha-2 adrenergic receptors, showing promise for pain management, mood support, and neuroprotection.
Agmatine Research & Studies
01 Neuroprotection by agmatine: Possible involvement of the gut microbiome? ▸
Examines agmatine's neuromodulatory properties as a neuroprotectant in brain aging, focusing on cell metabolism regulation and neurotransmitter signaling.
View Study (PubMed)02 Neuroprotective offerings by agmatine ▸
Reviews agmatine's neuroprotective effects across CNS models, demonstrating benefits against oxidative stress and neurotoxicity.
View Study (PubMed)03 Agmatine as a novel candidate for rapid-onset antidepressant response ▸
Investigates agmatine's potential for fast antidepressant effects by modulating stress and inflammation pathways similar to ketamine.
View Study (PubMed)04 Perspectives on Agmatine Neurotransmission in Acute and Chronic Stress-related Conditions ▸
Analyzes agmatine's stress-reduction mechanisms including glucocorticoid level reduction and mTOR/NMDA pathway modulation.
View Study (PubMed)05 Agmatine as a novel intervention for Alzheimer's disease: Pathological insights and cognitive benefits ▸
Demonstrates agmatine's capacity to modulate Alzheimer's pathology including amyloid beta processes with observed cognitive improvements.
View Study (PubMed)06 Agmatine modulation of gut-brain axis alleviates dysbiosis-induced depression-like behavior in rats ▸
Shows agmatine reversed depression-like behaviors in dysbiotic rats by restoring gut microbiota and reducing inflammation.
View Study (ScienceDirect)Agmatine User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Users commonly report pain relief, improved mood, and enhanced workouts. It's particularly popular in the fitness community for pump enhancement.
Agmatine Benefits, Dosage & Side Effects
- Pain Relief: Many users report significant reduction in neuropathic and chronic pain.
- Mood Support: Some users experience antidepressant-like effects and reduced anxiety.
- Enhanced Pumps: Popular among weightlifters for improving blood flow and muscle pumps.
- Potentiates Other Substances: Can enhance the effects of kratom, cannabis, and other compounds.
- Consistent Results: Most users report noticeable effects within the first week.
- Tolerance Neutral: Unlike many compounds, agmatine doesn't seem to cause tolerance.
- Typical Range: 250mg-2.5g daily, often divided into multiple doses.
- With Food: Can be taken with or without food.
- Pre-Workout: Often dosed 30-60 minutes before exercise.
- Generally Well Tolerated: Side effects are rare at typical doses.
- GI Discomfort: Some users report mild digestive issues.
- Blood Pressure: May lower blood pressure; caution for those on BP medications.
- Widely Available: Found at most supplement retailers.
- Affordable: One of the more cost-effective nootropics.
Community Reviews
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