HOLY BASIL (TULSI)
What Is HOLY BASIL (TULSI)?
Holy Basil (Ocimum sanctum/tenuiflorum), also known as Tulsi, is an adaptogenic herb traditionally used in Ayurvedic medicine that contains bioactive compounds including orientin, eugenol, and alpha-linolenic acid. It functions by modulating stress response pathways, exhibiting antioxidant properties, and influencing immune system function through effects on inflammatory mediators and hormone regulation. Primary uses include stress management, immune support, respiratory health, and as an anti-inflammatory agent.
HOLY BASIL (TULSI) Research & Studies
01 Ocimum flavone Orientin as a countermeasure for thrombocytopenia ▸
Orientin from Holy Basil significantly increased platelet production in mice by stimulating megakaryopoiesis, showing potential for treating thrombocytopenia without affecting other blood cell types.
View Study (PubMed)02 Biological activities of Ocimum sanctum L. fixed oil--an overview ▸
Holy Basil seed oil demonstrated anti-inflammatory, antipyretic, analgesic, and antiulcer activities through dual inhibition of arachidonate metabolism and antihistaminic effects, with an LD50 of 42.5 ml/kg and no adverse effects at therapeutic doses.
View Study (PubMed)03 Induction of resistance to respiratory tract infection with Klebsiella pneumoniae in mice fed on a diet supplemented with tulsi (Ocimum sanctum) and clove (Syzgium aromaticum) oils ▸
Dietary supplementation with Tulsi oil for 30 days significantly reduced bacterial colonization in respiratory tract infections by modulating immune responses and reducing oxidative stress markers.
View Study (PubMed)04 Ocimum gratissimum retards breast cancer growth and progression and is a natural inhibitor of matrix metalloproteases ▸
Holy Basil extract inhibited breast cancer cell invasion and tumor growth by suppressing MMP-2 and MMP-9 activities, reducing angiogenesis and basement membrane disintegration in xenograft models.
View Study (PubMed)05 Assessment of genotoxicity and acute oral toxicity of a standardized Ocimum tenuiflorum extract (Holixer™) ▸
Comprehensive safety testing showed no mutagenic or genotoxic effects of standardized Holy Basil extract up to 5000 µg/plate in bacterial and mammalian tests, demonstrating good safety profile.
View Study (PubMed)06 Modulation of growth performance, gut morphometry, and cecal microbiota in broilers by clove (Syzygium aromaticum) and tulsi (Ocimum sanctum) supplementation ▸
Tulsi supplementation improved gut health, morphometry, and beneficial microbial populations in broilers, suggesting potential as a natural alternative to antibiotic growth promoters.
View Study (PubMed)07 Enhanced In Vitro Plant Morphogenesis of Tobacco: Unveiling Indoleamine-Modulated Adaptogenic Properties of Tulsi (Ocimum sanctum L.) ▸
Tulsi extract demonstrated adaptogenic properties by modulating stress responses and indoleamine compounds, resulting in nearly doubled regeneration rates in plant tissue culture systems.
View Study (PubMed)08 Effect of combined herbal feed additives on methane, total gas production and rumen fermentation ▸
Tulsi in combination with other herbs significantly reduced methane production during rumen fermentation without affecting digestibility, suggesting environmental benefits for livestock.
View Study (PubMed)HOLY BASIL (TULSI) User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
No Reddit user experiences were provided in the dataset, preventing sentiment analysis. The research literature suggests positive safety and efficacy profiles across multiple biological systems.
HOLY BASIL (TULSI) Benefits, Dosage & Side Effects
- Immune Enhancement: Stimulates immune function through increased lymphoid organ development and enhanced resistance to respiratory infections
- Anti-inflammatory Action: Dual inhibition of inflammatory pathways including arachidonate metabolism and histamine release
- Adaptogenic Properties: Modulates stress responses through effects on indoleamines and endogenous growth regulators
- Antioxidant Activity: Reduces oxidative stress markers including lipid peroxidation and enhances cellular protection mechanisms
- Respiratory Support: Long-term supplementation (30 days) showed significant reduction in bacterial colonization and enhanced resistance to respiratory infections
- Platelet Production: Demonstrated specific enhancement of megakaryopoiesis and platelet formation without affecting other blood cell types
- Anti-cancer Properties: Inhibited tumor growth and progression through MMP suppression and reduced angiogenesis in preclinical models
- Safety Profile: Multiple toxicity studies confirm no mutagenic effects and good tolerance at therapeutic doses with LD50 of 42.5 ml/kg for oil
- Extract Concentration: 20% tulsi leaf extract showed optimal effects in biological systems for adaptogenic and growth-promoting properties
- Oil Supplementation: 0.5-1.5% concentration in diet or drinking water for immune-enhancing effects based on animal studies
- Duration: Short-term (15 days) vs long-term (30 days) supplementation, with longer duration showing more consistent benefits
- Standardization: Standardized extracts tested up to 5000 µg/plate without toxicity, suggesting wide therapeutic window
- Minimal Toxicity: Long-term use at 3 ml/kg dose in animal studies produced no adverse effects on organ function
- No Genotoxicity: Comprehensive testing showed no mutagenic or chromosomal aberration effects at tested concentrations
- Specificity: Platelet-enhancing effects showed no impact on other hematologic parameters, indicating selective action
- Drug Interactions: Potential considerations for those on anticoagulant therapy due to platelet-enhancing effects
- Supplement Forms: Available as standardized extracts, oils, leaf powder, and whole dried leaves in various commercial preparations
- Regulatory Status: Marketed as dietary supplement in the US with varying compliance to labeling requirements; traditional Ayurvedic use
- Quality Considerations: Standardized extracts (e.g., Holixer™) with defined active compound content offer more consistent dosing compared to raw herb preparations
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