Kisspeptin
What Is Kisspeptin?
Kisspeptin is a neuropeptide that plays a crucial role in reproductive hormone regulation. It stimulates GnRH release, which triggers the production of LH and FSH. Research explores its use for fertility, hypogonadism, and hormone optimization.
Kisspeptin Research & Studies
01 Kisspeptin and its Current Clinical Status- A Systematic Review ▸
Kisspeptin is presented as a multipurpose drug with fewer side effects, promoting normal physiological processes in various conditions.
View Study (Bentham Science)02 Kisspeptin and Polycystic Ovary Syndrome ▸
Research indicates higher kisspeptin levels in PCOS women, suggesting an overactive KISS1 system may contribute to irregular menstrual cycles.
View Study (Frontiers)03 Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation ▸
Kisspeptins and KISS1R play crucial roles in implantation and placentation, with levels potentially serving as diagnostic markers.
View Study (Oxford Academic)04 The kisspeptin-GnRH pathway in human reproductive health and disease ▸
Kisspeptin plays a key role in human reproduction; manipulating its signaling may offer novel therapies.
View Study (Oxford Academic)05 The role of kisspeptin in the control of gonadotrophin secretion ▸
Kisspeptins regulate the hypothalamic-pituitary-gonadal axis and reproduction, integrating signals from internal and external sources.
View Study (Oxford Academic)06 There is Kisspeptin – And Then There is Kisspeptin ▸
Kisspeptin regulates glucose homeostasis, insulin secretion, food intake, and body composition.
View Study (Cell Press Journal)07 Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males ▸
Elevating kisspeptin-54 significantly increases circulating LH, FSH, and testosterone levels in human males.
View Study (LWW Journals)Kisspeptin User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Limited user reports as it's primarily used in clinical/research settings. Those using for hormone optimization report mixed results. More commonly discussed in fertility contexts.
Kisspeptin Benefits, Dosage & Side Effects
- LH/FSH Release: Stimulates luteinizing and follicle-stimulating hormones.
- Testosterone Support: May increase testosterone through LH stimulation.
- Fertility: Researched for treating certain causes of infertility.
- Sexual Function: Some evidence for improved libido.
- Clinical Applications: Primary use in clinical fertility treatment.
- Variable Response: Effects on testosterone vary individually.
- Pulsatile Dosing: Natural kisspeptin signaling is pulsatile.
- Research Protocols: Variable depending on application.
- Clinical Use: Typically IV or subcutaneous administration.
- Timing: Often used in pulsatile fashion to mimic physiology.
- Limited Data: Safety profile in recreational use not well established.
- Hormonal Effects: Can significantly impact reproductive hormones.
- Injection Site Reactions: Possible with subcutaneous administration.
- Research Chemical: Available from select peptide suppliers.
- Specialized Use: Not as commonly available as other peptides.
- Clinical Setting: Most experience from clinical trials.
Community Reviews
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