LL-37
What Is LL-37?
LL-37 is a human antimicrobial peptide (cathelicidin) that plays a crucial role in innate immunity. It has antibacterial, antiviral, and antifungal properties, and also modulates inflammation and wound healing.
LL-37 Research & Studies
01 The structure of the antimicrobial human cathelicidin LL-37 shows oligomerization and channel formation in the presence of membrane mimics ▸
LL-37 creates a narrow tetrameric channel in bacterial cell walls, causing cell wall damage and cell death.
View Study (Springer Nature)02 Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice ▸
LL-37 improves survival in septic mice by suppressing macrophage pyroptosis and inflammatory cytokine production.
View Study (Oxford Academic)03 LL-37: Cathelicidin-related antimicrobial peptide with pleiotropic activity ▸
LL-37 exhibits broad-spectrum antibiotic activity with chemotactic and immunomodulatory properties.
View Study (ScienceDirect)04 The Human Cathelicidin Antimicrobial Peptide LL-37 and Mimics are Potential Anticancer Drugs ▸
LL-37 and its fragments demonstrate potential anticancer effects across various cancer cell lines.
View Study (Frontiers)05 A comprehensive summary of LL-37, the factotum human cathelicidin peptide ▸
LL-37 exhibits pleiotropic antibacterial, antifungal, antiviral, and chemotactic properties with immunostimulatory effects.
View Study (ScienceDirect)06 The human cathelicidin peptide LL-37 inhibits pancreatic cancer growth by suppressing autophagy and reprogramming of the tumor immune microenvironment ▸
LL-37 inhibits pancreatic cancer growth through autophagy suppression and immune microenvironment reprogramming.
View Study (Frontiers)LL-37 User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Used primarily for immune support and infection management. Users with chronic infections report benefits. More common in clinical and biohacking contexts.
LL-37 Benefits, Dosage & Side Effects
- Antimicrobial: Active against bacteria, viruses, and fungi.
- Immune Modulation: Helps regulate immune response.
- Wound Healing: Promotes tissue repair and regeneration.
- Biofilm Disruption: Can help break down bacterial biofilms.
- Broad Spectrum: Active against many types of pathogens.
- Immune Support: May help with chronic or recurring infections.
- Synergy: Sometimes combined with other antimicrobial peptides.
- Typical Range: 100-500mcg subcutaneously.
- Frequency: Often daily or every other day during acute use.
- Duration: Cycles vary depending on indication.
- Injection Site Reactions: Redness and irritation common.
- Inflammatory Response: May initially increase inflammation.
- Limited Safety Data: Long-term use not well studied.
- Research Chemical: Available from peptide suppliers.
- Specialized Use: Not as common as other peptides.
- Quality Critical: Purity important for injectable use.
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