MODAFINIL
What Is MODAFINIL?
Modafinil is a wakefulness-promoting agent originally developed to treat narcolepsy, shift work sleep disorder, and sleep apnea. It has gained popularity as a cognitive enhancer due to its ability to promote alertness and improve focus without the jittery effects of traditional stimulants.
MODAFINIL Research & Studies
01 Modafinil Treatment of Cocaine Dependence: A Systematic Review and Meta-Analysis ▸
Analysis of 11 trials assessing modafinil's effectiveness for treating cocaine dependency, concluding it is not generally superior to placebo, though US subgroup analysis showed some promise for abstinence.
View Study (PubMed)02 Caffeine and modafinil modulate the effects of sleep deprivation on thalamic resting-state functional connectivity ▸
Both substances affected functional brain connectivity after 36 hours of sleep deprivation, providing insights into neural mechanisms and potential strategies for mitigating cognitive impairment.
View Study (ScienceDirect)03 Modafinil Therapy and Mental Status Following Aneurysmal Subarachnoid Hemorrhage ▸
Modafinil improved alertness and orientation shortly after administration in aSAH patients, suggesting beneficial effects for early mental recovery in acute care settings.
View Study (ScienceDirect)04 Effects of modafinil on nocturnal sleep patterns in patients with narcolepsy ▸
Modafinil improved daytime sleepiness without significantly worsening nighttime sleep, reducing awakenings in females and increasing sleep onset latency in children/adolescents.
View Study (ScienceDirect)05 Chronic administration of caffeine, modafinil, AVL-3288 and CX516 induces time-dependent complex effects on cognition and mood ▸
In sleep-deprived mice, caffeine reduced anxiety and enhanced memory over time; AVL-3288 and CX516 improved cognition without depression-like effects, unlike other substances tested.
View Study (ScienceDirect)06 Effects of modafinil on epileptiform activity in absence epilepsy ▸
Modafinil significantly reduced both number and duration of epileptic seizures in absence epilepsy models, suggesting potential as a preventive treatment.
View Study (ScienceDirect)07 Comparison of Solriamfetol and Modafinil on Arousal and Anxiety-Related Behaviors in Narcoleptic Mice ▸
Both drugs promoted wakefulness effectively; solriamfetol did so without significant anxiety or locomotor increases, while modafinil induced anxiety-related behaviors.
View Study (ScienceDirect)08 Atomoxetine promotes incentive value of modafinil and sensitizes exploratory behavior ▸
Combined modafinil and atomoxetine showed noradrenergic system increases addictive potential and exploratory behavior in rats.
View Study (ScienceDirect)09 Modafinil exerts anticonvulsive effects against lithium-pilocarpine-induced status epilepticus in rats ▸
Modafinil decreased seizure severity and brain inflammation in status epilepticus, potentially through TNF-α and nitric oxide pathway mechanisms.
View Study (ScienceDirect)10 Modafinil ameliorates the decline in pronunciation-related working memory caused by sleep deprivation ▸
Modafinil significantly improved task accuracy and response times compared to placebo in sleep-deprived men, counteracting cognitive decline from acute sleep deprivation.
View Study (ScienceDirect)MODAFINIL User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Users generally report positive experiences with modafinil for productivity and focus, though individual responses vary. Many consider it effective for demanding cognitive tasks.
MODAFINIL Benefits, Dosage & Side Effects
- Enhanced Wakefulness: Primary effect is sustained alertness for 10-15 hours without the crash associated with caffeine or amphetamines.
- Improved Focus: Users report enhanced ability to concentrate on complex tasks for extended periods.
- Reduced Fatigue: Effective at combating both physical and mental fatigue.
- Highly Effective for Sleep Disorders: Proven efficacy for narcolepsy and shift work disorder.
- Cognitive Enhancement: Mixed evidence for healthy individuals, but many users report subjective benefits.
- Tolerance Development: Some users report diminished effects over time with daily use.
- Standard Dose: 100-200mg once daily, typically in the morning.
- Starting Low: Many recommend starting with 50-100mg to assess tolerance.
- Timing: Best taken early in the day to avoid sleep interference.
- Headache: Most common side effect, often mitigated by staying well-hydrated.
- Appetite Suppression: Many users experience reduced hunger.
- Insomnia: Can occur if taken too late in the day.
- Rare but Serious: Stevens-Johnson syndrome has been reported in rare cases.
- Prescription Required: Modafinil is a Schedule IV controlled substance in the US.
- Generic Availability: Generic versions are significantly cheaper than brand name Provigil.
- Online Sources: Various international pharmacies offer modafinil, though legality varies by country.
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