PTEROSTILBENE
What Is PTEROSTILBENE?
Pterostilbene is a naturally occurring polyphenolic compound, primarily found in blueberries and grapes, that is a dimethylated analog of resveratrol with superior bioavailability. It functions as a potent antioxidant, anti-inflammatory agent, and sirtuin activator, with effects on cellular metabolism, epigenetic regulation, and NAD+ pathways. Research suggests applications in metabolic health, cognitive function, longevity, and cancer prevention.
PTEROSTILBENE Research & Studies
01 Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions ▸
Review examining NAD+ precursor supplementation including nicotinamide riboside co-administered with pterostilbene, finding these compounds are common candidates for improving physiologic function in aging and age-related diseases.
View Study (PubMed)02 Pterostilbene Targets Hallmarks of Aging in the Gene Expression Landscape in Blood of Healthy Rats ▸
Pterostilbene supplementation in healthy rats modulated gene expression related to key aging hallmarks, suggesting anti-aging effects at the molecular level through epigenetic mechanisms.
View Study (PubMed)03 A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals ▸
Clinical trial examining NR and pterostilbene supplementation effects on muscle regeneration and stem cell function in elderly individuals following muscle injury.
View Study (PubMed)04 Pterostilbene, a dimethylated analog of resveratrol, promotes energy metabolism in obese rats ▸
Study found pterostilbene significantly suppressed abdominal fat accumulation, increased oxygen consumption and energy expenditure, and promoted fat metabolism over carbohydrate metabolism in obese rats.
View Study (PubMed)05 Pterostilbene-induced changes in gut microbiota composition in relation to obesity ▸
Pterostilbene supplementation induced beneficial changes in gut microbiota composition associated with improvements in obesity-related metabolic parameters.
View Study (PubMed)06 AMPK-Dependent Epigenetic Regulation of Metabolism Mediates the Anti-Cancer Action of Pterostilbene in Hepatocellular Carcinoma ▸
Pterostilbene demonstrated anti-cancer effects in hepatocellular carcinoma through AMPK-dependent epigenetic regulation of metabolism, suggesting potential therapeutic applications.
View Study (PubMed)07 Dietary Pterostilbene for MTA1-Targeted Interception in High-Risk Premalignant Prostate Cancer ▸
Dietary pterostilbene showed promise for cancer prevention in high-risk premalignant prostate cancer through targeted molecular mechanisms, supporting its potential for nutritional intervention.
View Study (PubMed)08 Pterostilbene enhances reproductive outcomes and oocyte quality in aged mice without adverse effects ▸
Long-term pterostilbene supplementation improved reproductive outcomes, increased implantation and live birth rates in aged mice, and enhanced oocyte quality without affecting estrous cycles or offspring health.
View Study (PubMed)PTEROSTILBENE User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Users report pterostilbene as an effective longevity and anti-aging supplement, particularly when combined with NAD+ precursors like NR. Most users taking it as part of comprehensive stacks report positive results for energy, cognitive function, and overall health markers, though it's rarely used alone.
PTEROSTILBENE Benefits, Dosage & Side Effects
- Longevity Support: Users report taking pterostilbene as part of anti-aging protocols, often combined with NAD+ precursors, with some reporting reversed epigenetic age markers
- Energy and Metabolism: Users note improvements in energy levels and metabolic function when pterostilbene is included in comprehensive supplement stacks
- Cognitive Function: Some users report enhanced mental clarity and cognitive performance, particularly when stacked with other nootropics
- Cardiovascular Benefits: Users incorporate pterostilbene for cardiovascular health and atherosclerosis reduction as part of broader heart health protocols
- Synergistic Effects: Most effective when combined with NAD+ boosters like NR or NMN, with users reporting the combination works better than either alone
- Bioavailability Advantage: Users choose pterostilbene over resveratrol due to its superior absorption and lipophilicity, noting it's more cost-effective despite higher price
- Long-term Benefits: Users report sustained benefits over months to years, particularly for anti-aging goals, with some showing measurable improvements in biomarkers
- Individual Variation: Effectiveness varies significantly between users, with some reporting dramatic results while others notice minimal changes
- Standard Dose: Most commonly used at 50-150mg daily, often as part of combination products with NR
- Timing: Typically taken in the morning on empty stomach or with breakfast as part of longevity stacks
- Cycling: Some users cycle pterostilbene as part of senolytic protocols rather than taking daily
- Stack Integration: Usually combined with 250-300mg NR, quercetin, fisetin, and other longevity compounds
- Minimal Reported: Very few direct side effects attributed to pterostilbene specifically in user reports
- Stack Interactions: Users occasionally report difficulty determining which compound in complex stacks causes effects or side effects
- Cost Concerns: High cost is the main complaint, with users seeking more affordable alternatives or questioning cost-effectiveness
- Limited Standalone Data: Most users take it in combination, making it difficult to isolate specific side effects
- Commercial Products: Available from supplement companies, often combined with NR in branded products like Basis and Tru Niagen
- Quality Brands: Users prefer brands like Jarrow Formulas and products from Renue by Science that provide third-party testing
- Food Sources: Naturally found in blueberries, though supplemental doses are much higher than dietary intake
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