Semax
What Is Semax?
Semax is a Russian peptide derived from ACTH with potent nootropic and neuroprotective effects. It increases BDNF, enhances cognitive function, and is approved in Russia for stroke, cognitive disorders, and peptic ulcers.
Semax Research & Studies
01 The efficacy of semax in the tretament of patients at different stages of ischemic stroke ▸
Early rehabilitation and semax administration increased BDNF levels in post-stroke patients, improving motor performance.
View Study (PubMed)02 Effectiveness of semax in acute period of hemispheric ischemic stroke ▸
Semax at doses of 12-18 mg improved neurological function and motor skills in acute ischemic stroke patients.
View Study (PubMed)03 Semax, synthetic ACTH(4–10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure ▸
Semax mitigated behavioral and biochemical complications from neonatal SSRI exposure in rats.
View Study (ScienceDirect)04 Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity ▸
Semax binds metal ions and reduces copper-induced toxicity in nerve cells.
View Study (ScienceDirect)05 Influence of the N-terminus acetylation of Semax on copper(II) and zinc(II) coordination ▸
Acetyl-modified Semax altered metal ion binding but may have potential future applications in cancer therapies.
View Study (ScienceDirect)06 Semax, an analogue of adrenocorticotropin (4–10), for the treatment of attention-deficit hyperactivity disorder ▸
Researchers propose Semax as an alternative to psychostimulants for ADHD treatment.
View Study (ScienceDirect)07 Degradation of ACTH/MSH(4–10) and its synthetic analog semax by rat serum enzymes ▸
Aminopeptidases and angiotensin-converting enzyme primarily degrade Semax in rat serum.
View Study (ScienceDirect)08 Semax as a Universal Drug for Therapy and Research ▸
Review analyzing 1980-2016 data on Semax's benefits including anxiety reduction and cognitive enhancement.
View Study (Institute of Molecular Genetics)09 Meta-analysis: Semax effectiveness in the acute period of stroke ▸
Semax significantly reduced stroke severity and improved mobility compared to placebo.
View Study (PubMed)10 Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction ▸
Semax effectively restored immune balance in socially stressed laboratory animals.
View Study (Astrakhan State Medical University)Semax User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Highly effective for focus and mental clarity. Users report significant cognitive enhancement and neuroprotection. More stimulating than selank; some prefer combining both.
Semax Benefits, Dosage & Side Effects
- BDNF Increase: Significantly elevates brain-derived neurotrophic factor.
- Enhanced Focus: Improved concentration and mental clarity.
- Memory Boost: Better working and long-term memory.
- Neuroprotection: Protects neurons from damage and promotes repair.
- Mild Stimulation: Provides mental energy without anxiety.
- Fast Acting: Effects often felt within 30 minutes intranasally.
- Reliable Results: Consistent cognitive enhancement.
- Synergy: Often combined with selank for balanced effects.
- Typical Range: 200-600mcg intranasally, 1-3 times daily.
- N-Acetyl Semax: More potent variant requiring lower doses.
- Subcutaneous: Can also be injected.
- Generally Safe: Few side effects reported.
- Nasal Irritation: Minor with intranasal use.
- Stimulation: May be too stimulating for some users.
- Hair Loss: Rare reports; may be from BDNF effects on hair cycle.
- Research Chemical: Available from peptide suppliers.
- Russian Medication: Approved and widely used in Russia.
- Multiple Forms: Available as standard semax or N-Acetyl variant.
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