Sulbutiamine
What Is Sulbutiamine?
Sulbutiamine is a synthetic derivative of thiamine (vitamin B1) developed in Japan that crosses the blood-brain barrier more effectively. It's used to combat fatigue, enhance memory, and may modulate dopamine transmission.
Sulbutiamine Research & Studies
01 Role of the Synthetic B1 Vitamin Sulbutiamine on Health ▸
Reviews sulbutiamine's potential applications including anti-fatigue, nootropic, and antioxidant effects, plus possible roles in treating infections and cancer.
View Study (PubMed)02 Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection-associated asthenia ▸
Large study (1772 patients) found sulbutiamine effective in reducing fatigue when used alongside anti-infective treatments.
View Study (PubMed)03 Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine versus placebo ▸
Study on postinfectious fatigue showed temporary improvement in women taking higher doses, though no significant effects observed at conclusion.
View Study (PubMed)04 Effects of sulbutiamine (Arcalion 200) on psycho-behavioral inhibition in major depressive episodes ▸
Sulbutiamine added to standard treatment helped alleviate psycho-behavioral inhibition in major depressive disorder patients.
View Study (PubMed)05 Effects of the association of sulbutiamine with an acetylcholinesterase inhibitor in early stage and moderate Alzheimer's disease ▸
In Alzheimer's patients, sulbutiamine combined with acetylcholinesterase inhibitor improved attention and episodic memory.
View Study (PubMed)06 Sulbutiamine shows promising results in reducing fatigue in patients with multiple sclerosis ▸
Sulbutiamine significantly reduced fatigue scores in MS patients, particularly those receiving disease-modifying treatments.
View Study (ScienceDirect)Sulbutiamine User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Users appreciate its fatigue-fighting and mood-enhancing properties. Some report improved motivation and reduced shyness. Tolerance can develop with daily use.
Sulbutiamine Benefits, Dosage & Side Effects
- Anti-Fatigue: Significantly reduces mental and physical fatigue.
- Mood Enhancement: May improve mood and motivation.
- Memory Support: Enhanced memory formation and recall.
- Social Anxiety: Some users report reduced social inhibition.
- Dopamine Modulation: May upregulate dopamine receptors.
- Fast Acting: Effects often noticed same day.
- Tolerance Issues: Can lose effectiveness with daily use.
- Cycling Recommended: Best used intermittently.
- Typical Range: 200-600mg daily, often divided.
- Cycling: Many recommend 2-3 times per week maximum.
- With Food: Better absorbed with dietary fat.
- Generally Safe: Few side effects at normal doses.
- Insomnia: May disrupt sleep if taken late.
- Tolerance: Effectiveness diminishes with daily use.
- Headaches: Occasionally reported.
- Supplement: Available from nootropic vendors.
- Prescription in Europe: Sold as Arcalion in some countries.
- Moderate Cost: Mid-range pricing.
Community Reviews
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